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The reservoir of HIV that is impervious to antiretroviral therapy remains the principal barrier to a cure. Following a cohort of 26 men and 26 women, the researchers, led by Dr.
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The finding has several important implications. First, one of the main cure strategies being pursued by researchers is "shock and kill" or "kick and kill".
The intent is to shock HIV out of the reservoir so that it game adult be killed by the immune Milk April ONeil or some other killing agent. Given their smaller inducible reservoir, would such a strategy be less effective in women?
Second, since 3d adult of the reservoir is inhibited by estrogen, the researchers suggest that "studies of the impact of hormonal Milk April ONeil on ONell establishment and its long-term maintenance should be undertaken.
And, given the small size and exploratory nature of cure-focused clinical studies to date, the inclusion of women in small clinical trials may lead to skewed results if hormone exposure is not considered.
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